I suspect that the issue is not Centrify-related, but ideally you run current software.
Remember, we retired our Centrify-enhanced Samba earlier this year due to the Badblock vulnerability. Make sure you're running the latest version of this as well.
To find out the Centrify version, in your CentOS systems, run the "adinfo --version" command.
If you're running 5.2.1, you have to upgrade due to many reasons (including EoL as of August 2017).
Since you did not implement this, I'd do more data gathering internally.
R.P